Hypericumperforatum L. Showed Antinociceptive Effects Through Opioidergic And Serotonergic Systems

Figure 6: Pre-treatment with intrathecal injection of Naloxane(Nal) 5μg /rat on analgesia induced by intraperitoneal injection of 400mg/kg aqueous extract Hp on Tail flick test.(n=6). A. Predrug □ and post drug■ latency were measured. Nalderceased latency time significantly(*p<0.05 by paired t-test) AND Hp increased latency time (***p<0.001). B. Maximum possible effect (MPE) unchanged by Nalpretreatment (*p<0.5, un-paired t-test).

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