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Hypericumperforatum L. Showed Antinociceptive Effects Through Opioidergic And Serotonergic Systems

Figure 5: Pre-treatment with intrathecal injection of Naloxane (Nal)5μg /rat on analgesia induced by intraperitoneal injection of 400mg/kg aqueous extract Hpof the second phase of the formalin test.(n=6). Naloxane significantly reduced antinociceptive effects of Hp extract in comparing Saline-Saline(sal-sal) group(***p<0.001), Sal-Nal(++p<0.01) and Meth-Hp(###p<0.01). One-way ANOVA with post-hoc Tukey Test.

Pre-treatment with intrathecal injection of Naloxane (Nal)5μg /rat on analgesia induced by intraperitoneal injection of 400mg/kg aqueous extract Hpof the second phase of the formalin test.(n=6). Naloxane significantly reduced antinociceptive effects of Hp extract in comparing Saline-Saline(sal-sal) group(***p<0.001), Sal-Nal(++p<0.01) and Meth-Hp(###p<0.01). One-way ANOVA with post-hoc Tukey Test.
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