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Hypericumperforatum L. Showed Antinociceptive Effects Through Opioidergic And Serotonergic Systems

Figure 2: Pre-treatment with intrathecal injection of Methysergid (Methy)30μg /rat on analgesia induced by intraperitoneal injection of 400mg/kg aqueous extract Hpof the second phase of the formalin test.(n=6). Methysergid significantly reduced antinociceptive effects of Hp extract in comparing Saline-Saline (sal-sal) group(***p<0.001), Sal-Methy (+++p<0.001) and Meth-Hp(###p<0.01). One-way ANOVA with post-hoc Tukey Test.

Pre-treatment with intrathecal injection of Methysergid (Methy)30μg /rat on analgesia induced by intraperitoneal injection of 400mg/kg aqueous extract Hpof the second phase of the formalin test.(n=6). Methysergid significantly reduced antinociceptive effects of Hp extract in comparing Saline-Saline (sal-sal) group(***p<0.001), Sal-Methy (+++p<0.001) and Meth-Hp(###p<0.01). One-way ANOVA with post-hoc Tukey Test.
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