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Hypericumperforatum L. Showed Antinociceptive Effects Through Opioidergic And Serotonergic Systems

Figure 1: Pre-treatment with intrathecal injection of Methysergide(Methy)30μg /rat on analgesia induced by intraperitoneal injection of 400mg/kg aqueous extract Hpof the first phase of the formalin test. (n=6). Methysergid significantly reduced antinociceptive effects of Hp extract in comparing Saline-Saline(sal-sal) group(***p<0.001), Sal-Methy(+++p<0.001) and Meth-Hp(##p<0.01). One-way ANOVA with post-hoc Tukey Test.

Pre-treatment with intrathecal injection of Methysergide(Methy)30μg /rat on analgesia induced by intraperitoneal injection of 400mg/kg aqueous extract Hpof the first phase of the formalin test. (n=6). Methysergid significantly reduced antinociceptive effects of Hp extract in comparing Saline-Saline(sal-sal) group(***p<0.001), Sal-Methy(+++p<0.001) and Meth-Hp(##p<0.01). One-way ANOVA with post-hoc Tukey Test.
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